Dr Thomas Gervais, Ph.D.
Assistant professor of engineering physics and biomedical engineering;
École Polytechnique de Montréal, Institut de Génie Biomédical, CRCHUM (associate researcher) et Institut du cancer de Montréal.
2000 B. Ing., École Polytechnique de Montréal, Engineering Physics
2006 Ph.D., Massachusetts Institute of Technology (MIT), Bioengineering (Course 20), with Profs Peter K. Sorger and Klavs F. Jensen
- 2016-2019 (co-PI), FRQS
"Stratégies multimodales pour le traitement ciblé de cancers à haut risque"
- 2016-2018 (PI), Individual Grant, FRQNT
"Sonde microfluidique multipolaire pour le marquage de haute précision de tissus in vitro"
- 2015-2017 (co-PI), Operating Grant,
“Translating molecular science to soft-tissue sarcoma treatments”
- 2015-2017 (co- PI), Operating Grant, Cancer Research Society (CRS),
“Ovarian tumors on-chip : quantitative tools to predict chemoresponse using patient-specific proliferation assays”
- 2015 (co-PI), Innovation Fund, Canadian Foundation for Innovation (CFI),
"Infrastructure for micro-imaging and optical glass processing (#33372)"
- 2014-2019 (PI), Discovery Grant, National Science and Engineering Research Council (NSERC),
“Open microfluidic platforms for the in vitro assessment of tumor response to drugs”
- 2014-2016 (co-PI) Innovation operating grant, Canadian Cancer Society Research Institute (CCSRI),
“Microfluidic based empirical testing versus predictive biomarkers to stratify cancer care in ovarian cancer patients.”
- 2013-2015 (co-PI) Movember discovery grant, Prostate Cancer Canada,
“Validation and use of a microfluidic platform to test prostate cancer response to targeted therapies »
- 2013-2014 (co-PI) Explore grant, Consortium Québécois de Développement du médicament.
“Circumventing the need for predictive biomarkers in personalized ovarian cancer therapies: empirical chemosensitivity testing using a microfluidics-based multiplex platform"
Awards and prizes
2016 Student award, Best graduate level instructor in biomedical engineering, Polytechnique Montréal
2013 Student Award, Best instructor in engineering physics, Polytechnique Montréal
2012 Best audio audio/video report award, Gala de l’Association des Journalistes Indépendants du Québec (AJIQ)
2011 Student award, Best instructor, Polytechnique Montreal
2011 Best audio/video piece award, Gala de l’Association des Journalistes Indépendants du Québec (AJIQ)
2006 Prix de la relève, Bourse de Journalisme Scientifique Fernand-Seguin, Radio-Canada
2000 Da Vinci Profile, École Polytechnique de Montréal
Tumors-on-chip, Open microfluidics, Mathematical modelling of reagents, nutrients and metabolites transport on-chip and in microtumors.
Theoretical fluid mechanics and analysis of transport phenomena
In this somewhat vast field of research, our group has contributed directly to the development of a new type of 3D cancer model for drug discovery and treatment response analysis called microdissected tumors (MDT). These tumor samples are extracted through surgery or biopsy, cut to submicroliter sizes, and loaded in specially designed microfluidic chip for culture and analysis. Our results have revealed that they can be maintained alive on-chip for several days, a period sufficient to perform drug response assays.
Our group is also actively involved in mathematical modelling of complex Stokes flow in open microfluidics geometries. These flows are a the core of several technologies including microfluidic probes, hanging drop spheroid culture platforms, orthogonal flow mixers, etc.
Our research relies on strong collaborations with cancer biologists and clinicians at the CRCHUM and Institut du Cancer de Montreal to ensure its direct translation into clinical applications.
A few of our undergoing projects are listed below:
- Development of microdissected tissue (MDT) as an ex vivo model for personalized medicine and treatment response assessment (Guay-Lord, Rousset; collaborations with A-M Mes-Masson, F. Saad, D. Provencher)
- Development of a fluorescence spectroscopic imager for the quantitative on-chip analysis of tumor response to drugs (A. St-Georges-Robillard ; collaborations with A-M Mes-Masson and F. Leblond)
- Development of an on-chip culture environment to study the effect of chemotheraphy and radiotherapy treatment on 3D tumor samples (MDTs and spheroids) (Brunet, Patra, Bairos, St-Georges-Robillard; collaboration with A-M Mes-Masson, P. Wong)
- Mathematical modeling of multipolar flows and applications to the design of novel microfluidic probes (Boulais, Goyette; collaborations with D. Juncker (McGill))
- Design, fabrication and testing of microfluidic probes (Guay-Lord, Goyette)
- Mathematical modeling of biochemical transport in microfluidic surface-based sensors.
- Fundamental microfluidics (seeking new applications to store, deliver reagents and exploit new transport processes at the micro and nanoscale) (S. Castonguay, O. Gökçe; collaboration with E. Delamarche (IBM research – Zurich))
- Amélie St-Georges-Robillard, Ph.D. Candidate, Amelie.St-Georges-Robillard@polymtl.ca
- Alexandre R. Brunet, M.Sc. Candidate, Alexandre.R-Brunet@polymtl.ca
- Étienne Boulais, Ph.D.. Candidate, Etienne-2.Boulais@polymtl.ca
- Robin Guay-Lord, M.Sc. Candidate, Robin.Guay-Lord@polymtl.ca
- Pierre-Alexandre Goyette, M.Sc. Candidate, Pierre-Alexandre-F.Goyette@polymtl.ca
- Samel Castonguay, Ph.D. Candidate, email@example.com
- Maeva Bavoux, M.Sc. A. Candidate, firstname.lastname@example.org
- Mélina Astolfi, M.Sc.
- Dr Mohana Marimuthu, Ph.D.
- Nassim Rousset, M.Sc.
- Dr Bishnubrata Patra, Ph.D.
- Julia Bairos, M. Eng.
- Rousset N, Monet F, Gervais T. “Simulation-assisted design of microfluidic sample traps for optimal trapping and culture of non-adherent single cells, tissues, and spheroids”. Scientific Reports, 7: 245, pp. 1-12, 2017, DOI: 10.1038/s41598-017-00229-1
- Astolfi M, Péant B, Lateef MA, Rousset N, Kendall-Dupont J, Carmona E, Provencher D, Saad F, Mes-Masson AM, Gervais T, “Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy”, Lab Chip, 2016;16:312-325
- Safavieh M., Qasaimeh M.A., Vakil A., Juncker D., Gervais T, “Microfluidic probes as flow dipoles: theory and applications”, Scientific Reports, vol 5, p. 11943, 2015, DOI: 10.1038/srep11943
- Tawil N., Altef A., Sacher E., Maisonneuve M., Gervais T, Mandeville R., Meunier M., « Surface Plasmon Resonance Determination of the Binding Mechanisms of L-Cysteine and 11-Mercaptoundecanoic Acid on Gold », J. Phys. Chem. C, 2013
- Das T, Meunier L, Gervais T, Barbe L, Guenat O, Provencher D, Mes-Masson AM, “Empirical Chemosensitivity Testing in a Spheroid Model of Ovarian Cancer using a Microfluidics-based Multiplex Platform”, Biomicrofluidics, 2013;7(1):11805.
- Qasaimeh, M. A., Gervais T., Juncker D. « Microfluidic quadrupole and floating concentration gradients », Nature Communications, 2:464, 2011.
- T. Gervais, J. El-Ali, A. Günther, and K. F. Jensen, Flow-Induced deformation of shallow microfluidic channels, Lab Chip, 2006, 6, 500–7.
- T. Gervais and K. F. Jensen, Mass transport and surface reactions in microfluidic systems, Chem. Eng. Sci., 2006, 61, 1102–1121.